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Objectives:
Due to development of new devices, the study of the nasal aerodynamics
has acquired an ever-increasing value, especially during recent years.
This is accounted for by the fact that with the advent of a special
device (Y.P.Ulyanov, P.P.Polivanov, 1988), it has become possible to
examine separate air flows in the nasal passages both at inspiration
and expiration, to establish the normogram of the nasal aerodynamics
and to determine its two extreme variants: "the northern" and the
"southern" (Y.P.Ulyanov, 1995, 1996, 1997). Patients with the "northern"
type are better adapted to the harsh air of the mid-latitude temperate
zone and probably therefore they catch a cold very seldom (once in 4-5
years). Persons with the "southern" type of aerodynamics are less
protected in this aspect. They catch a cold regularly in autumn and
winter more than once, forming the population of those disposed to
epidemics of influenza. As a result, resistance of patients to acute
rhinitis caused by common cold is in fact a qualitative criterion of
efficiency of the protective properties of nasal aerodynamics. This
correlation is especially clearly demonstrated after surgical
reconstruction of the "northern" type of aerodynamics out of the
"southern" one (Y.P.Ulyanov, 1997). The otherwise, after this surgical
reconstruction of nasal aerodynamics the dry and subatrophic mucosa of
nose becomes soft and moist without any signs of inflammation, and
resistant to common colds of the wet seasons.
METHODS
Therefore at present, having at our disposal the extreme variants
of the protective properties of nasal aerodynamics are as the
criteria of their efficiency, we can examine all transitional forms
and evaluate them from the clinical point of view.
During endonasal rhinomanometry, we studies of nasal aerodynamics
in 1000
patients with frequent fits of common cold and 300 practically healthy
people facilitated detection of clinical manifestations of 2 extreme
types of nasal aerodynamics, which had been observed previously by
scientists. These are the "northern" type of nasal aerodynamics (NTA)
and the "southern" type of nasal aerodynamics (STA).
Using the principle of moving the main airstream at inspiration from
MM
to IM, patients were divided into 7 nasal aerodynamics groups, with
airstream pressures differing from each other by 10 conditional units
(CU) = 25 Pascal (Pa).
MM at inspiration. Table 1.
In Table 1, distribution of airstream at inspiration between IM and MM
appears to be the main distinctive criterion of groups of patients with
various values for nasal aerodynamics. The age range of patients was 2-86
years with a 1:1 male-to-female ratio. Clinical manifestations of different
diseases in each of the nasal aerodynamic groups are marked with (+) to
indicate less than 5% incidence, with (++) to indicate 6-10% incidence,
and with (+++) to indicate incidence over 11%.
RESULTS:
Healthy patients adapted to average and northern latitudes made up 3 groups
with 150-200 Pa entering MM at inspiration. Patients with regular seasonal
colds were in 4 groups with airstream pressures of 50-125 Pa entering
Apart from the detection of 2 extreme types of nasal aerodynamics, as
the "northern" and "southern" type of nasal aerodynamics has been established
and group of patients with complete equilibrium of the distribution of air
flows between middle and inferior nasal passages (50 CU/50 CU). The patient
of this group as and other three groups with 50-125 Pa (40 CU, 30 CU and 20 CU)
had caught a cold frequently. At the same time, among the persons who were
practically healthy and possess the "northern" type of aerodynamics there
are two more groups with 150-200 Pa (60 CU and 70 CU)were well adapted to
average and northern latitudes. The entry of the air flow through the
superior nasal passage was approximately stable (10 CU in each group)
and was not related to the distribution of air flows along the other
nasal passages. As a result, 250 Pa (100 CU) were to go through the inferior
and medial nasal passages. E.g., in the "southern" type of aerodynamics
20 CU go through the medial nasal passage, with 80 CU entering the inferior
nasal passage. In patients with the "northern" type of aerodynamics, the
situation was reverse, i.e. 80 CU go through the medial nasal passage, with
20 CU entering the inferior nasal passage. Clinical manifestations of these
variants of distribution of the air flows were especially evident
(Second part of Table 1).
|  |
 |
Table 1. Variants of distribution of airstream among nasal passages at
inspiration
|
| Nasal passages |
1,000 persons with
seasonal catch a cold. |
300 practically
healthy persons. |
| Olfactory area (Pascal) |
25 |
25 |
25 |
25 |
25 |
25 |
25 |
| Middle meatus (Pa.) |
50 |
75 |
100 |
125 |
150 |
175 |
200 |
| Inferior meatus (Pa.) |
200 |
175 |
150 |
125 |
100 |
75 |
50 |
Clinical manifestations
|
Annual occurrence
rate of catch a colds |
1-2 |
2-4 |
2-3 |
1-2 |
Catch a cold
once for 4-5 years |
| Otitis |
- |
+ |
+ + |
+ |
- |
- |
- |
| Sinusitis |
+ |
+ + |
+ + + |
+ + |
- |
- |
- |
| Vasomotor rhinitis. |
- |
+ + |
+ + + |
+ + + |
+ |
- |
- |
| Subatrophic mucosa of SRW |
+ + + |
+ + + |
+ + |
+ |
+ |
- |
- |
| Atrophic mucosa of SRW |
+ + |
- |
- |
- |
- |
- |
- |
| Tracheobronchitis |
+ + + |
+ + |
+ |
- |
- |
- |
- |
| Laryngospasms |
+ |
+ |
- |
- |
- |
- |
- |
| Bronchial asthma |
+ + |
+ |
- |
- |
- |
- |
- |
| Pneumonia |
+ + |
+ |
+ |
- |
- |
- |
- |
| Ozena |
+ + |
- |
- |
- |
- |
- |
- |
The data of the Table demonstrate that appearance of rhinitis in
directly depended upon the shift of the main air flow from the
medial nasal passage to the inferior one. As long as the main air
flow at inspiration entered through the medial nasal passage,
patients caught a cold very seldom (once in 4-5 years), however,
a slightest disturbance of this situation, be it only in 10 CU, with
the distribution of air flows becoming an equal value (50/50),
patients suffer from colds every year (up to twice a year). The
further shift of the air flow to the inferior nasal passage increases
the trend to two to three colds annually (with an additional 10 CU)
and to four colds a year (with an additional 20 CU). However, further
shift of the air flow to the inferior nasal passage (to 80 CU) causes
a fifty-percent drop in the advent of seasonal cold of the superior
respiratory ways, which suggests a contradiction to the above-mentioned
trend and demands the further investigation. Therefore, we have
carried out an additional analysis of correlations between clinical
manifestations as related to the level of the shift of the air flow
to the inferior nasal passage one. The leading place among the
clinical manifestations is held by the subatrophic process of the
mucosa of the nose, larynx and pharynx to be seen even in the group
of healthy persons with 60 CU. Whereas a further shift of the air
flow to the inferior nasal passage was causes the next increased
subatrophic process with the maximum value to be reached in the
persons with the "southern" type of nasal aerodynamics, when the
atrophic process is already detected. The latter seems to be not so
much evident in the "southern" nasal aerodynamics, so that the mucosa
cannot probably respond with the protective inflammatory reaction in
the form of acute rhinopharyngitis caused by seasonal colds with the
occurrence rate being half as high. A false conclusion comes to mind
that the atrophic process as if protects us from common cold. But is
it so? It turns out that in this group of patients a deeper involvement
of the inspiratory ways in the form of tracheobronchitis which occur
less frequently as long as the air flow returns to the medial nasal
passage, with a nearly complete disappearance when the equilibrium
of the air flows is reached. Moreover, this group of patients suffer
from fits of laryngospasms, and bronchial asthma, with the
inflammatory process reaching even the lungs, often causing pneumonia.
Therefore, excessive dryness of the mucosa of the superior
inspiratory ways, while reducing the occurrence rate of acute seasonal
rhinopharyngitis, lets the harsh air pass into the inferior
inspiratory ways causing more severe diseases such as tracheobronchitis,
bronchial asthma, and pneumonia, which is a further confirmation of
the detected main trend. i.e. a correlation between the status of the
inspiratory ways and the level of redistribution of the air flow at
inspiration between the medial and inferior nasal passages, i.e. the
evident protective properties of the nasal aerodynamics. This
correlation is also corroborated by local clinical manifestations
near the nose. Acute rhinitis is detected in groups with the air flow
values at inspiration from 50 to 40 or 30 CU. Sinusitis is seen in
groups with 50-40, 30 and 20 CU, with the following association taking
place. The more pronounced mucosal atrophy is, the less frequently it
occurs, but at the same time there is a risk of ozena. The reduced
protective response of the mucosa with increased subatrophic process
and appearance of atrophy is confirmed also by manifestations of
vasomotor rhinitis which is so aggressive that affect even
practically healthy persons in the group till 60 CU, but it occurs
frequently also in the group with 30 CU, although it is not
practically found in the group with 20 CU. Having studied certain
correlations of the distribution of the air flow at inspiration, we
cannot but take into account also the distribution of the air flow at
expiration, as the latter affects the rate of compensatory influence
of the warm and humid air flow on the mucosa of the inferior nasal
passage damaged by the "harsh" air at inspiration.
 |
 |
Table 2. Variants of redistribution of air flows in persons who frequently
catch cold
|
| Nasal Passages |
"Southern type of nasal aerodynamics - 33% |
Transitional variant |
Complete equlibrium |
| Medial nasal passageInspiration in CU |
- |
20 |
- |
- |
30 |
- |
- |
40 |
- |
- |
50 |
- |
| Inferior nasal passageInspiration in CU |
- |
80 |
- |
- |
70 |
- |
- |
60 |
- |
- |
50 |
- |
| Medial nasal passageExspiration in CU |
90 |
80 |
70 |
80 |
70 |
60 |
70 |
60 |
50 |
60 |
50 |
40 |
| Inferior nasal passageExspiration in CU |
90 |
10 |
20 |
30 |
20 |
30 |
40 |
30 |
50 |
40 |
50 |
60 |
These data are shown in Table 2
when applied to those people who frequently catch cold. As is seen from the Table 2 , in persons with the "southern" aerodynamics (divided into two subgroups), with 80 CU entering at inspiration through the inferior nasal passage (found in 15%), it is only 20 CU that went through the inferior nasal passage with variants from 10 to 30 CU. The mucosa of the superior inspiratory ways (SIW) had a dry and atrophic aspect. In the neighboring subgroup, with 70 CU entering at inspiration through the inferior nasal passage (found in 18%), it is only 30 CU that went through the inferior nasal passage with variants from 20 to 40 CU. The mucosa of the SIW had also a dry aspect against the background of pronounced subatrophic process. These two groups (with 20 and 30 CU) had the most obvious shifts of air flows at inspiration to the inferior nasal passage with a small difference between them in clinical manifestations. This is a basis for their integrating into one group of the "southern" type comprising 33% (15% + 18%). In the next group, with 60 CU entering at inspiration through the inferior nasal passage (found in 39% of those studied), at expiration 40 CU (with variants of 30 and below 50 CU) went through this passage. The mucosa of the SIW retains apparent signs of subatrophic process and looks irritated. In the extreme group of this type of patients, with the complete equilibrium in the distribution of air flows at inspiration (50/50 CU), found in 28% of cases, we have detected that at expiration, in addition to the complete equilibrium of 50 CU, there are also variants from 40 to 60 CU. The mucosa of the SIW was subatrophic, but without signs of irritation. Therefore, persons with an equal distribution of air flows (50/50 CU) who make up nearly a third (28%) and those with a slight shift of the air flow into the inferior nasal passage (a drop of 10 CU) who make up 39% represent the largest group of 67%. This group is characterized either by small alterations of the air flows or by equal flows, which has caused a considerable damage to the protective function of the nasal aerodynamics, so that these patents enter the group of those who catch cold frequently. Besides, in this group of patients as direct correlation was clearly found between the increasing development of the subatrophic process (reaching atrophy of the mucosa of the SIW) and an augmentation of the air flow entering at inspiration through the inferior nasal passage. These quantitative variants of the air flows at expiration took place at the expense of redistribution of the air flows between different halves of the nose, with the common air flow through the nose remaining stable. A study of the values of the nasal aerodynamics of practically healthy persons (Table 3)
 |
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Table 3. Variants of redistribution of air flows in practically healthy
persons
|
| Nasal passages |
Extreme variant in 37% |
Medial variant in 61% |
"Northern" type in 22% |
| Medial nasal passageInspiration in CU |
- |
60 |
- |
- |
70 |
- |
- |
80 |
- |
| Inferior nasal passageInspiration in CU |
- |
40 |
- |
- |
30 |
- |
- |
20 |
- |
| Medial nasal passage Exspiration in CU |
50 |
60 |
70 |
60 |
70 |
80 |
70 |
80 |
90 |
| Inferior nasal passageExspiration in CU |
50 |
40 |
30 |
40 |
30 |
20 |
30 |
20 |
10 |
has shown that in all of them the main flow at inspiration entered through the medial nasal passage (from 60 to 80 CU) and that distribution of them among variants was rather uniform. In the extreme groups, 60 CU were registered in 37% of cases, and 80 CU in 22%, which makes up 59%, whereas the medium group (with 70 CU) includes 61%. With 60 CU coming at inspiration through the medial nasal passage and 40 CU through the inferior one, at expiration 50 to 70 CU went through the inferior nasal passage, with the subatrophic nasal mucosa being seen.passage, 30 CU came through the inferior one, and 60 to 80 CU went out at expiration through the inferior nasal passage, with no subatrophic signs detected. In patients with the "northern" variant, at inspiration 80 CU and 20 CU entered through the medial and inferior nasal passage, respectively, whereas at expiration 70 to 90 CU of the air flow went out through the inferior nasal passage with the nasal mucosa being soft and humid without any signs of inflammation. Clinically, these three groups were practically similar, as these patients caught cold very seldom. However, in the group with 60 CU phenomena of subatrophic mucosa, especially of the inferior nasal passages, could be seen, with vasomotor rhinitis being also observed in them.
CONCLUSION:
Clinical manifestations of reduction of the protective properties of nasal
aerodynamics, such as frequent colds with local complications (eg,
sinusitis, otitis, CR), occur in equal distribution of airstream between MM
and IM. Further moving of the main airstream into IM on inspiration is
accompanied by frequent colds and more serious complications with
compromise of respiratory passageways, leading all the way to ozena,
bronchial asthma, and pneumonia.
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Uliyanov Y.P. Method reconstruction of nasal aerodynamics. Jor. Vrach,
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